江西体彩11选5多乐彩走势图今天 www.phcnlx.com.cn Two landmark events occurred for CAR-T cell therapy in 2017: two anti-CD19 CAR-T cells were approved by FDA for the therapy of acute lymphoblastic leukemia (ALL) and relapsed or refractory large B-cell lymphoma, respectively. From then, increasing number of researchers have been dedicated to CAR-T cell therapy research.
What is CAR-T cell therapy?It is a kind of cell immunotherapy featured by its distinct research procedures (depicted in Fig. 1): Peripheral blood is collected from the patient firstly. Then T cells are isolated and stimulated. The cells are cultured and expanded after genetically engineered to express chimeric antigen receptors (CARs), which can recognize a specific tumor associated antigen, such as CD19, BCMA and CD20. Finally, the CAR-T cells will go through quality control and are reinfused into the patient.
Sino Biological Inc. provides not only quality CAR-T cell therapy target proteins, but also varied research reagents for the whole process of CAR-T cell therapy, such as high-quality cytokines, T cell related FACS antibodies, T cell activation antibodies, cytokine ELISA kits, apoptosis detection kits, Sinofection tranfection reagents and Supernuclease.
Procedure | Research reagents |
T cell isolation and activation | ? T cell activation antibodies |
T cell genetically engineering | ? CAR-T cell therapy targets for biopanning |
? Sinofection tranfection reagents for lentiviral vectors transfection | |
? Supernuclease for removing DNA impurities in the process of lentiviral vector amplification. | |
CAR-T cell expansion | ? High-quality cytokines for CAR-T cell culturing |
CAR-T cell quality control and infusion into the body | ? CAR-T cell therapy targets for detecting CAR+% |
? T cell related FACS antibodies | |
? Cytokine ELISA kits | |
? Annexin V/7-AAD apoptosis detection kits for cytotoxicity assay |
Sino Biological Inc. have successfully developed over 6000 proteins, covering most of the investigational CAR-T cell therapy targets. We have developed biotinylated proteins and fluorescent labeled proteins to simplify your research procedures. The proteins with high purity and binding activity, have been validated in high-class citations. Therefore, CAR-T cell therapy target proteins in Sino Biological Inc. are the first choice for your scientific research. To view more about the CAR-T cell therapy targets.
Target | Purity (by HPLC) | Endotoxin (EU/mg) | Cat. No. |
Human CD3 (humanized OKT3) | >95% | <0.5 | 10977-H001 |
Human CD28 | >95% | <0.5 | 11524-H001 |
? Sinofection tranfection reagents for lentiviral vectors transfection
? Supernuclease for removing DNA impurities in the process of lentiviral vector amplification.